P-52: Effects of Curcuma Longa Extract on Sperm Parameters with High Fructose Diet Rats

Background: Obesity and increased body mass index (BMI) affect the reproductive parameters in men such as poor semen quality, decreased sperm concentration, decreased normal-motile sperm cells and increased DNA fragmentation index. Lipid peroxidation contributes to the damage of the sperm plasma membrane. The Curcuma Longa is a resource of antioxidants, hence in this study also was evaluated the effect of Curcuma Longa extract on sperm parameters in rats with diet containing fructose pay. Materials and Methods: Wistar albino male rats, approximately 150-200 g divided into 3 groups: control diet during 10 weeks of study (group I), diet with high fructose (group II) and diet with high fructose treated by Curcuma Longa extract. After 10 weeks, animals were killed and sperm parameters analysis was done. Results: The results of this study revealed the significant increase in sperm count in group III (49.4 × 106 per ml) rather than group II (38.2 × 106 per ml), and sperm count in group II (37.8 × 106 per ml) was reduced rather than groups I and II, significantly. But progressive motility of sperm in groups II and III (28.5% and 29.7%, respectively) was lower than group I (35.8%), but there was no significant differences between sperm morphology and viability of three groups. Conclusion: The results of this study suggested that sperm count is affected by diet with high fructose, so that decreases with high fructose diet and Curcuma Longa extract could increase the sperm count. But Curcuma Longa extract consumption can cause to decrease of sperm motility.